plasma androgen造句

• This seemingly paradoxical result is due to the overexpression of Cyp4a12a; the knockout of Cyp4a14 ( Cyp4a14 does not produce 20-HETE ) leads to the overexpression of the 20-HETE-producing cytochrome, Cyp4a149 (-/-), and consequent overproduction of 20-HETE . The model involves increased plasma androgens, increased vascular and urinary levels of 20-HETE, relief of hypertension by castration, and hypertension which is driven by excessive fluid reabsorption in the kidney's proximal tubule secondary to the overexpression of Sodium hydrogen antiporter 3; these effects are presumed but not yet shown to be due to the overproduction of 20-HETE . The Cyp4a12-transgenic model ( above ) is referred to in support of this presumption.